No specific tuning is required to run OpenVMS or Tru64 UNIX on Avanti.  Use of the fastest available host hardware will help improve overall performance.  Using quality host hardware components will improve overall system reliability.

Alpha CPU's process commands sequentially.  There is no known method of distributing CPU commands across multiple host CPUs that provides performance gains.

Utilizing a low-performance host system, overloading the amount of memory available to the virtual Alpha system, and excessive I/O will have negative performance consequences, just as on a real AlphaServer.  Tuning the O/S may help rectify the situation.  If not, consider using a more powerful host system or reducing the workload.  If FreeAXP is in use, consider upgrading to Avanti with the JIT option.

A common problem when Avanti is hosted in a VM such as VMware is over commitment of the VM host hardware.  I.e. Running to many VMs on a single host.  Ensure adequate resources are allocated to the VM hosting Avanti.