If running multiple instances of Avanti, it is recommended that each instance be assigned its own host NIC.  If this is the case, then the MAC addressing scheme described in Single Avanti Instance and MAC Addressing holds true and manual MAC assignments should not be necessary.

If multiple instances of Avanti share a single host NIC, then the MAC addressing scheme will assign each instance the same set of MAC addresses.  This will lead to network address conflicts and block network access on all but the first instance.  If a single host NIC is to be shared between Avanti instances, then manual configuration of the MAC addresses on each instance is required to ensure proper network functionality.